Go to a S.H.E.I.L.D. save zone and select "Change Team". Delete all selected characters. Once all of your team slots are empty, press: Left, Left, Right, Right, Up, Down, Up, Down, Start. A sound will confirm correct code entry. Note: This code may also be enabled at the main menu.

Go to a S.H.E.I.L.D. save zone and select "Change Team". Delete all selected characters. Once all of your team slots are empty, press: Down, Left, Left, Up, right, Up, Down, Left, Start. A sound will confirm correct code entry. Note: This code may also be enabled at the main menu.

Enter these codes at the specified area to get the listed effect:

Do the following tasks to unlock the following character or mode.

Create a team with the indicated characters to receive the corresponding bonus.

Gain between two and four levels with a character. Alternately, defeat 30 enemies with a character to unlock his or her second costume. Defeat 175 enemies with a character to unlock his or her second costume.

Complete the Combat Training challenge for a character. Alternately, get a "Bronze" rank in a character's Comic Mission to unlock his or her fourth costume.

Use the following trick to make a hard to kill team. Make a team consisting of Wolverine, Blade, Ghost Rider, and Luke Cage (the Bad To the Bone team). The team bonus will be that 5% of all damage will regained as health. Also, all these characters have a way to regenerate health. Equip he following outfits. For Wolverine, Astonishing, Max Out Health Regen and Defense. For Blade, Ultimate, Max Out Health Regen and Defense. For Luke Cage, New Avengers, Max out Health Regen and Defense. For Ghost Rider, Original, Max out Resurrect Ally and Defense. It is also recommended that Ghost Rider be equipped with The Heart of Mephisto (10% of attack damage turned into health) or a similar item because he is the only character without a Health Regen. Equip other characters with gear that increases defense or dodging capabilities. Not only will your team be difficult to hurt, but they will be absorbing and regenerating most of the damage they take. If a teammate dies, Ghost Rider will have a 50% chance of resurrecting them. Note that Ghost Rider is the weak point. He does not regenerate, and if he dies resurrection is lost. Also, Wolverine will regenerate the fastest because he has an inherit ability to regenerate in addition to the suit's bonus.

When picking up character specific items, such as "Iron Man's Coil", it is described as doing +3 Damage and +3 Rocket Uppercut. This is not +3 to damage for the hit; it means that it adds three dots in the Powers area. With this single item you can go from 129 Damage to 289 Damage. Character specific gear are thus very valuable.

When lighting the candles in Mephisto's Realm, there is an area where you are meant to throw the demon jumpers into the fire to lower the pedestal. If you stand in by the edges of the level where the jumpers respawn, you can kill as many as desired. Try this as Spider-Man or any rapid fire projectile user. The enemies constantly drop money and energy refills. If one walks too far away, hopefully your teammates will chase after them and you can use the momentum move to wipe them out. Do this for easy experience and money.

Do not be afraid of the hard difficulty setting. When you start a game under hard mode, you can load your characters from a previously saved game. For example, if you have a level 50 Wolverine from normal mode, you can start the game with him and all his powers, gear, and costumes that you have gained. It also adds five more dots to level up your powers with. If you have one maxed out in normal mode, there is even more room for improvement.

To complete all the Comic missions easily and unlock Silver Surfer and get gold at the same time, wait and play all the missions at the end of the game when your characters have leveled up and have decent powers. If some are still to difficult to complete, do some Versus mode missions with those characters to level them up, or to pick up some Shield Tokens to add to their costume.

When you get to the end of the mission to battle Ultimo, run back to the door you came in. Ultimo is so big he cannot pass the edge of the room he is in. You can just sit back and hit him with your ranged attacks. Then when needed, fly in and collect the health and energy vials he drops.

After the third level, go to Iron Man's lab and talk to Spider-Man. He will say "The only thing that could make this worse is if Earth was blown up to make an intergalactic highway".

After you complete the game, start new game. Before you unlock Ghost Rider in Mephisto's Realm, put the Ghost Rider from your completed game on your team. Then, unlock Ghost rider. Make sure that you do not replace Ghost Rider with the new Ghost Rider. You should now have two Ghost Riders on your team.