Make sure to get all the Duff Beer Caps, Krusty Koupons, Marge's Coupons, and Malibou Stacy Cards to unlock items for Pet Homer and Clich's. Note: You can go back to older levels to use new powers you have unlocked. Also in the for the first level, "Chocolate Land", go to the Simpson's house and tap the thought bubble.

When using Pet Homer, tap his right knee to make him kick. Tap his left foot to tickle him.

An easy way to finish the Mythos of Marge level is to stand in the ash tray and wait for the dragon to return there. Punch it while it is inside the ash tray. You will not be harmed by the fire because there is an invisible shield in the ash tray.